ASD_Seeker

Open-source screening-support over a public ABIDE I reference space. It shows how one subject's brain-imaging features deviate from a normal reference, which evidence markers contribute, and how uncertain the read is.

ABIDE I · C-PAC · CC200 (200 ROI) strict-QC n = 937 AUROC 0.91 — internal model (release pending) FDA-uncleared · not stand-alone
Start here

📋 1-page summary

Decision-first triage for one subject: a verdict band, the recommended next step, and a behavior-first anchor. Covers all 1257 subjects.

NormalinconclusiveASD

Open summary →

Go deeper

🔬 In-depth analysis

Seven interactive tabs: functional-network deviation map, 3D brain, age/sex norms, cortical surface, evidence markers, model facts. Each opens with a plain-language clinical lens.

Ships a 40-subject offline sample — opens with no install, no server.

Open in-depth →

✓ No install · no server · just open index.html

How it works

  1. Public brain-MRIABIDE I · ADHD-200
  2. Extract featuresbrain-network connectivity
  3. Compare to Normalreference brain
  4. How different?which networks?
  5. Clinician decidesone clue, not a diagnosis

How to read a result

🔵 Normal-leaning⚪ inconclusive🔴 ASD-leaning
🔵 toward Normal

Does NOT rule out autism.

⚪ inconclusive

Defer — rely on behavioral assessment.

🔴 toward ASD

A statistical signal, not a diagnosis.

✅ Behavioral assessment (ADOS · SRS · developmental history) stays the clinical standard. Imaging is an adjunct.

Performance — honestly

NumberWhat it is
AUROC 0.91Internal validated model — public release pending. The headline target; its data/weights are not in this repo, and the live demo does not use it.
AUROC 0.626The model this demo actually runs: ABIDE I, leave-one-site-out (honest cross-site). Per-site AUC 0.31–0.73 across 20 sites.
AUROC 0.743Clinic pooled 5-fold (in-sample, optimistic vs LOSO).

Leakage guard: any pooled cross-site AUC above ~0.78 on ABIDE is a red flag. The deployed honest number is 0.626 LOSO.

How to read the colors

Warm / red = ASD-leaning (higher / excess) · Cool / blue = Normal-leaning (lower / deficit) · deeper color = larger deviation. A result "toward ASD" is a statistical deviation, not a diagnosis; "toward Normal" does not rule autism out.